Headwater Science

Headwater Science develops and applies advanced study designs, analytic frameworks, and technology that consequential evidence increasingly requires, for research partners, regulators, payers, HTA bodies, and peer-reviewed literature. Observational research is increasingly evaluated against the same standards once reserved for randomized trials. Pre-specification. Protection against bias. Sensitivity analyses. Transparency in design and analytic choice. The ability to withstand scrutiny from reviewers who did not run the study. Headwater Science exists to meet that bar. Our work spans three connected capability areas: • Methods: advanced techniques across causal inference, pharmacoepidemiology, and study design, including target trial emulation, clone-censor-weight designs, negative control outcome studies, fusion designs and estimators, propensity score diagnostics, and the staging and clean room framework for transparency and bias protection. • Technology: platforms that operationalize advanced methods at scale, supporting pre-specification, reproducibility, audit-readiness, and the analytic transparency regulatory and HTA reviewers increasingly expect. Designed to work across data sources rather than tied to any single research environment. • Partnerships: study design, analytic strategy, regulatory submission preparation, and methodological review of observational research across the full range of decisions where methodological complexity affects whether evidence will hold up. We work with life sciences partners, academic research groups, regulatory consulting firms, and other research organizations. Our methods are deployed wherever the question requires them, across sponsor-owned data assets, claims databases, electronic health records, and other research data sources. Headwater Science is a portfolio company of Highlander Health. Headwater Science was formerly NoviSci. Learn more at headwaterscience.com